Description

3β,5,14,19-Tetrahydroxy-5β-Bufa-20,22-Dienolide is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and their therapeutic potential. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel cardiac glycosides and other bioactive steroid derivatives.
• Biochemical Research: Used as a reference standard or active compound in pharmacological studies targeting Na+/K+-ATPase enzyme inhibition.
• Preclinical Development: Serves as a starting material or intermediate for the development of potential therapeutic agents for heart conditions.
• Academic Research: Employed in university and institutional labs for studying the structure-activity relationships (SAR) of bufadienolides.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.

Basic Information

Product Name	3β,5,14,19-Tetrahydroxy-5β-Bufa-20,22-Dienolide
CAS No.	508-79-2
Molecular Formula	C₂₄H₃₄O₆
Molecular Weight	418.53 g/mol
Synonyms	3β,5,14,19-Tetrahydroxy-5β-bufa-20,22-dienolide; Bufadienolide A; 19-Hydroxybufalin; 5β,14β-Bufadienolide-3β,5,14,19-tetrol; 3β,5β,14β,19-Tetrahydroxybufa-20,22-dienolide; Telocinobufagin; 19-Hydroxyresibufogenin
EINECS	Contact for details

Quality Control

Our 3β,5,14,19-Tetrahydroxy-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.