Description

Cymarin CAS NO 508-77-0 is a potent cardiac glycoside derived from plants of the *Apocynaceae* family, primarily *Strophanthus kombe*. This high-purity compound serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for the development of cardiovascular therapeutics. It is essential for pharmaceutical R&D, quality control laboratories, and manufacturers of cardiac medications requiring precise and reliable bioactive components.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and purity testing of cardiac glycoside drugs and herbal extracts via HPLC, LC-MS, and TLC.
• Cardiovascular Drug Research: Serves as a key intermediate and biochemical tool in R&D for novel positive inotropic agents targeting heart failure.
• Biochemical Studies: Employed in pharmacological research to study Na+/K+-ATPase inhibition, calcium ion regulation, and myocardial contractility mechanisms.
• Herbal Extract Standardization: Acts as a marker compound for the quality control and standardization of botanical preparations containing *Strophanthus* species.
• Academic Research: Utilized in university and institutional labs for teaching and investigating the structure-activity relationships of glycosides.

Basic Information

Product Name	Cymarin
CAS No.	508-77-0
Molecular Formula	C30H44O9
Molecular Weight	548.67 g/mol
Synonyms	K-Strophanthin-α; Cymarine; K-Strophanthoside-α; Strophanthin α; Cymarol 3-O-α-L-Cymaroside; Apocynamarin; (3β,5β,14β)-3-[(2,6-Dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
EINECS	208-089-4

Quality Control

Our Cymarin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets high-grade standards suitable for pharmaceutical research. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	+23° to +27° (c=1 in Methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.