Description

Ouabagenin CAS NO 508-52-1 is the aglycone derivative of the potent cardiac glycoside ouabain, serving as a critical reference standard and biochemical tool. Its primary value lies in its specific activity as a high-affinity ligand for the sodium-potassium ATPase (Na⁺/K⁺-ATPase) pump, enabling detailed pharmacological and physiological studies. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly for investigating cardiovascular function, developing enzyme inhibitors, and producing analytical standards.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quality control and assay development of ouabain and related cardiac glycoside drugs.
• Biochemical Research: A key tool compound for studying the structure, function, and inhibition mechanisms of the Na⁺/K⁺-ATPase enzyme in cellular physiology.
• Cardiovascular Pharmacology: Employed in research models to investigate inotropic effects, ion transport, and signal transduction pathways in heart tissue.
• Enzyme Inhibition Studies: Acts as a specific inhibitor in assays to measure ATPase activity and to screen for novel modulators of ion transport.
• Metabolite and Impurity Analysis: Utilized in analytical methods (HPLC, LC-MS) for the identification and quantification of ouabain and its degradation products.
• Academic and Contract Research: Serves as a fundamental reagent in university laboratories and CROs (Contract Research Organizations) for basic and applied life science research.

Basic Information

Product Name	Ouabagenin
CAS No.	508-52-1
Molecular Formula	C₂₃H₃₄O₈
Molecular Weight	438.51 g/mol
Synonyms	Ouabagenin; Strophanthidin; 3β,5,11α,14,19-Pentahydroxy-5β-card-20(22)-enolide; G-Strophanthidin; Acocantherin; NSC 529634; 1β,3β,5,11α,14,19-Hexahydroxy-5β,14β-card-20(22)-enolide; Strophanthidine
EINECS	Contact for details

Quality Control

Our Ouabagenin is produced and tested under a strict quality management system to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. A Certificate of Analysis (COA) detailing specific results for purity, identity, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.