Description

Benzyl Chloroformate is a versatile and highly reactive organic compound primarily used as a key protecting group reagent in organic synthesis. Its primary value lies in its ability to introduce the benzyloxycarbonyl (Cbz or Z) group, a fundamental tool for the protection of amines in peptide and pharmaceutical manufacturing. This makes it an essential intermediate for researchers and production chemists in the pharmaceutical, agrochemical, and fine chemical industries. The compound's reactivity profile allows for selective transformations critical for building complex molecular architectures.

Application

• Peptide Synthesis: As a standard reagent for introducing the Cbz (Z) protecting group on amino acids, preventing unwanted side reactions during coupling steps.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Production: Used in the manufacture of certain herbicides, fungicides, and plant growth regulators where amine protection is required.
• Fine Chemical Synthesis: Employed in the laboratory and industrial-scale preparation of complex organic molecules, including dyes, flavors, and fragrances.
• Polymer Chemistry: Can be utilized in the synthesis of specialized polymers and functional materials.
• Bioconjugation: Applied in modifying biomolecules for research and diagnostic applications.

Basic Information

Product Name	Benzyl Chloroformate
CAS No.	501-53-1
Molecular Formula	C8H7ClO2
Molecular Weight	170.59 g/mol
Synonyms	Benzyloxycarbonyl chloride; Cbz-Cl; Z-Cl; Carbobenzoxy chloride; Chloroformic acid benzyl ester; Benzyl chlorocarbonate; Phenylmethyl chloroformate; NSC 2730
EINECS	207-925-0

Quality Control

Our Benzyl Chloroformate is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with the standards expected in cGMP environments for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated). This product is hygroscopic (moisture-sensitive) and reacts with water, strong acids, and bases. Keep away from heat, sparks, and open flame. Containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) to maintain purity and prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Density (at 20°C)	1.195 - 1.215 g/mL
Refractive Index (n20D)	1.516 - 1.520
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.