Description

Phenoxybenzamine CAS NO 59-96-1 is a potent, irreversible α-adrenergic receptor antagonist. This compound is of significant value in pharmaceutical research and development due to its specific mechanism of action, which allows for the study and modulation of adrenergic pathways. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of cardiovascular agents, urological treatments, and neurological research.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Core component in the manufacture of medications for conditions like pheochromocytoma and hypertensive crises.
• Biochemical Research: Essential tool for in vitro and in vivo studies to block α-1 and α-2 adrenergic receptors, elucidating their physiological roles.
• Preclinical Drug Development: Used in animal models to investigate the effects of adrenergic blockade on blood pressure, smooth muscle tone, and sympathetic nervous system activity.
• Reference Standard: Serves as a high-purity calibrant in analytical laboratories for quality control and method development (HPLC, GC-MS).
• Urological Research: Investigated for potential applications in managing urinary retention due to its effects on smooth muscle in the prostate and bladder neck.

Basic Information

Product Name	Phenoxybenzamine
CAS No.	59-96-1
Molecular Formula	C18H22ClNO
Molecular Weight	303.83 g/mol
Synonyms	Phenoxybenzamine Hydrochloride (common salt form); N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; Dibenzyline (brand name); Benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)amine; N-Phenoxyisopropyl-N-benzyl-β-chloroethylamine; PBZ; BZ-55
EINECS	200-456-7

Quality Control

Our Phenoxybenzamine is manufactured and tested under a strict quality management system. We provide material that meets high-purity standards suitable for research and pharmaceutical applications. Certificates of Analysis (COA) are available for every batch, detailing purity, identity, and impurity profiles. While we offer various grades, our standard material is produced with a focus on consistency and reliability for critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.