Description

Puromycin Aminonucleoside is a potent and specific nucleoside analog derived from the antibiotic puromycin. This compound serves as a critical biochemical tool for studying protein synthesis and cellular processes, particularly in renal research. It is primarily utilized by researchers and scientists in the fields of molecular biology, pharmacology, and nephrology. The product is supplied as a high-purity material suitable for laboratory and research applications.

Application

• Research Tool in Nephrology: Widely used to induce experimental models of nephrotic syndrome and podocyte injury in cell culture and animal studies.
• Protein Synthesis Inhibition Studies: Acts as a specific inhibitor of protein synthesis, useful for investigating translational mechanisms and ribosome function.
• Cell Biology Research: Employed to study apoptosis, cellular stress responses, and signal transduction pathways in various cell lines.
• Biochemical Assay Development: Serves as a reference standard or active component in assays designed to screen for protective compounds or therapeutic agents.
• Academic and Pharmaceutical R&D: Essential for basic research in universities and for drug discovery pipelines targeting kidney diseases and protein synthesis disorders.

Basic Information

Product Name	Puromycin Aminonucleoside
CAS No.	58-60-6
Molecular Formula	C12H18N6O4
Molecular Weight	310.31 g/mol
Synonyms	6-Dimethylamino-9-[3'-amino-3'-deoxy-β-D-ribofuranosyl]purine; 3'-Amino-3'-deoxy-N,N-dimethyladenosine; Puromycin Aminonucleoside; PAN; NSC 3055; 3'-Amino-3'-deoxy-N6,N6-dimethyladenosine; 3'-Aminonucleoside of Puromycin
EINECS	200-387-8

Quality Control

Our Puromycin Aminonucleoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Tested in cell-based assay (available on request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.