Description

Guanethidine CAS NO 55-65-2 is a potent antihypertensive agent belonging to the class of adrenergic neuron-blocking drugs. It functions by inhibiting the release of norepinephrine from sympathetic nerve endings, leading to a reduction in peripheral vascular resistance and blood pressure. This compound is primarily utilized in pharmaceutical research and development, serving as a critical reference standard and active pharmaceutical ingredient (API) for the formulation of specialized medications. Its reliable mechanism of action makes it a valuable tool for studying autonomic nervous system pharmacology and developing treatments for severe hypertension.

Application

• Pharmaceutical API: Serves as the active ingredient in the formulation of prescription medications for managing severe or treatment-resistant hypertension.
• Biochemical Research: Used as a key pharmacological tool in laboratory studies to investigate sympathetic nervous system function, neurotransmitter release, and adrenergic mechanisms.
• Reference Standard: Employed as a high-purity calibration standard in analytical chemistry for quality control (QC) and assurance (QA) testing of pharmaceutical products.
• Metabolic Studies: Applied in research to understand the drug's pharmacokinetics, metabolism, and elimination pathways.
• Veterinary Medicine: Investigated for potential use in managing hypertension in animals within veterinary pharmaceutical research.

Basic Information

Product Name	Guanethidine
CAS No.	55-65-2
Molecular Formula	C10H22N4
Molecular Weight	198.31 g/mol
Synonyms	Guanethidine Sulfate; (2-Hexahydro-1(2H)-azocinyl)ethyl]guanidine; Abapressin; Antipres; Dopom; Iporal; Ismelin; Octadine; Sanotensin; Visutensil; Eutensol
EINECS	200-248-8

Quality Control

Our Guanethidine is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical and research applications. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) detailing all test results is provided to guarantee traceability and compliance with relevant specifications. We support compliance with major pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can compromise product stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.