Description

2-Methyl-3-(3,4-Dihydroxyphenyl)-Dl-Alanine is a synthetic amino acid derivative, commonly known as DL-α-Methyldopa, which functions as a key intermediate in pharmaceutical synthesis. Its primary commercial value lies in its role as a precursor for the production of the antihypertensive agent L-α-Methyldopa, a critical medication for managing high blood pressure. This compound is essential for manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors who require high-purity, reliable intermediates for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of the antihypertensive drug L-α-Methyldopa (Aldomet®).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to catecholamine biosynthesis and metabolism.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Preclinical Development: Employed in the research and development of novel dopaminergic agents and cardiovascular drugs.
• Fine Chemical Synthesis: Utilized as a specialized intermediate for constructing complex molecules with catechol and amino acid motifs.

Basic Information

Product Name	2-Methyl-3-(3,4-Dihydroxyphenyl)-Dl-Alanine
CAS No.	55-40-3
Molecular Formula	C10H13NO4
Molecular Weight	211.22 g/mol
Synonyms	DL-α-Methyldopa; (±)-α-Methyldopa; DL-3-(3,4-Dihydroxyphenyl)-2-methylalanine; 2-Methyl-DOPA; Aldomet Intermediate; MK-351; NSC 113939; Lopam
EINECS	200-236-6

Quality Control

Our 2-Methyl-3-(3,4-Dihydroxyphenyl)-Dl-Alanine is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.