Description

Metyrapone CAS NO 54-36-4 is a potent and selective inhibitor of the enzyme 11β-hydroxylase, which plays a critical role in the biosynthesis of cortisol. This compound is of significant value in biochemical research and pharmaceutical development for modulating steroid hormone production. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and manufacturers of diagnostic reagents for investigating adrenal function and endocrine disorders.

Application

• Biochemical Research: Used as a specific inhibitor to study the steroidogenesis pathway and adrenal cortex function.
• Pharmaceutical Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the development of therapies for Cushing's syndrome and related endocrine conditions.
• Clinical Diagnostics: Employed in diagnostic tests, such as the metyrapone stimulation test, to assess pituitary-adrenal axis reserve and diagnose adrenal insufficiency.
• Endocrinology Studies: A vital tool for in vitro and in vivo research into cortisol regulation, stress response, and metabolic disorders.
• Reference Standard: Used for quality control and analytical method development in pharmaceutical and contract research laboratories.

Basic Information

Product Name	Metyrapone
CAS No.	54-36-4
Molecular Formula	C14H14N2O
Molecular Weight	226.27 g/mol
Synonyms	2-Methyl-1,2-di-3-pyridyl-1-propanone; Mepyrapone; SU-4885; Metopirone; Methopyrapone; 2-Methyl-1,2-bis(3-pyridyl)-1-propanone; 1,2-Di(pyridin-3-yl)-2-methylpropan-1-one
EINECS	200-204-7

Quality Control

Our Metyrapone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.