Description

D-Thyroxine is the dextrorotatory enantiomer of the thyroid hormone thyroxine (T4). This high-purity compound is critical for research and development in the life sciences, serving as a key reference standard and a building block for biochemical studies. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic institutions investigating thyroid hormone metabolism, receptor interactions, and enantiomer-specific biological activity.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay validation of levothyroxine (L-thyroxine) APIs and finished dosage forms.
• Biochemical Research: Essential for in-vitro studies exploring the stereospecificity of thyroid hormone action, enzyme kinetics, and metabolic pathways.
• Analytical Method Development: Serves as a critical standard in HPLC, LC-MS, and other chromatographic methods for separating and quantifying thyroxine enantiomers.
• Metabolic Studies: Employed in research to understand the differential effects of D- versus L-thyroxine on cholesterol metabolism and cardiac function.
• Diagnostic Reagent Component: Used in the development and calibration of immunoassays and other diagnostic kits for thyroid function testing.

Basic Information

Product Name	D-Thyroxine
CAS No.	51-49-0
Molecular Formula	C15H11I4NO4
Molecular Weight	776.87 g/mol
Synonyms	Dextrothyroxine; D-T4; (R)-Thyroxine; Dextrothyroxine Sodium (salt form); O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-D-tyrosine; 3,3',5,5'-Tetraiodo-D-thyronine; D-Thyroxin; Right-handed thyroxine
EINECS	200-101-1

Quality Control

Our D-Thyroxine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet stringent standards for research and reference material use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results for key parameters such as assay, enantiomeric excess, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% D-isomer
Water (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.