Description

5-Chloro-2'-Deoxyuridine is a halogenated pyrimidine nucleoside analog with significant biochemical and pharmaceutical relevance. This compound serves as a critical building block and research tool in the development of antiviral and anticancer agents, particularly those targeting DNA synthesis. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors. The product is supplied with a focus on high purity and batch-to-batch consistency to support advanced research and development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and antineoplastic (anticancer) drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidine kinase and DNA polymerases.
• Antiviral Agent Development: Investigated for its activity against DNA viruses, serving as a lead compound for drug discovery programs.
• Radiopharmaceuticals: Potential precursor for the synthesis of radiolabeled compounds used in diagnostic imaging and targeted radiotherapy.
• Cell Biology Studies: Utilized to study cell proliferation, DNA replication, and the mechanisms of nucleoside metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Chloro-2'-Deoxyuridine
CAS No.	50-90-8
Molecular Formula	C9H11ClN2O5
Molecular Weight	262.65 g/mol
Synonyms	5-Chloro-2'-deoxyuridine; 5-Cl-dU; 5-Chlorodeoxyuridine; NSC 38297; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-chloropyrimidine-2,4-dione; 5-Chloro-1-(2-deoxy-β-D-ribofuranosyl)uracil; Chlorodeoxyuridine
EINECS	200-063-8

Quality Control

Our 5-Chloro-2'-Deoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all test results are provided to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.