Description

5'-Azido-2',5'-Dideoxyinosine is a specialized nucleoside analog featuring an azido functional group at the 5' position. This compound is a critical synthetic intermediate and research tool in medicinal chemistry and biochemistry, valued for its unique reactivity and potential for click chemistry applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel antiviral agents, prodrugs, and molecular probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside-based antiviral and anticancer prodrugs.
• Bioconjugation & Click Chemistry: The azido group enables efficient, site-specific conjugation with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and modifying biomolecules.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled probes to study cellular uptake and localization of nucleoside analogs.
• Antiviral Research: Investigated for its potential activity or as a precursor to active metabolites against viral targets.
• Academic & Contract Research: Employed in university and CRO laboratories for exploratory synthetic chemistry and drug discovery projects.

Basic Information

Product Name	5'-Azido-2',5'-Dideoxyinosine
CAS No.	496809-83-7
Molecular Formula	C10H11N7O3
Molecular Weight	277.24 g/mol
Synonyms	5'-Azido-2',5'-dideoxyinosine; 9-[(2R,5S)-5-Azido-5-deoxy-β-D-erythro-pentofuranosyl]-9H-purin-6-ol; 5'-Azido-ddI; 5'-N3-2',5'-ddI; Azidodideoxyinosine; 5'-Azido-2',5'-dideoxy-6-hydroxypurine riboside
EINECS	Contact for details

Quality Control

Our 5'-Azido-2',5'-Dideoxyinosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.