Description

(S)-Gna-U-Phosphoramidite CAS NO 494784-15-5 is a high-purity, chiral phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. Its primary value lies in enabling the precise and efficient incorporation of modified nucleosides, which is essential for developing advanced therapeutic nucleic acids like antisense oligonucleotides and siRNAs. This product is indispensable for pharmaceutical R&D teams, biotechnology companies, and CROs focused on creating next-generation genetic medicines and molecular diagnostics.

Application

• Oligonucleotide Synthesis: Key monomer for the automated solid-phase synthesis of DNA/RNA strands, particularly for introducing site-specific modifications.
• Therapeutic Nucleic Acid Development: Critical raw material in the production of antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers for targeted therapies.
• Probe and Primer Manufacturing: Used to synthesize labeled or modified oligonucleotide probes and primers for advanced PCR, sequencing, and diagnostic assays.
• Research & Development: Enables academic and industrial research into nucleic acid chemistry, structure-activity relationships (SAR), and novel drug discovery platforms.
• Synthesis of Modified Nucleosides: Serves as a versatile intermediate for the chemical synthesis of complex, sugar-modified nucleoside analogs.

Basic Information

Item	Details
Product Name	(S)-Gna-U-Phosphoramidite
CAS No.	494784-15-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-[(2S,5R)-5-[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl-2-[(2-cyanoethoxy)(diisopropylamino)phosphanyl]oxyoxolan-3-yl]-5-methylpyrimidine-2,4-dione; (S)-Glycerol Nucleic Acid-U Phosphoramidite; (S)-GNA-U Phosphoramidite; (S)-GNA-U Phosphoramidite monomer; (S)-GNA thymine phosphoramidite; (S)-1,2-Propanediol nucleic acid U phosphoramidite; (S)-GNA-U-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Our (S)-Gna-U-Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity verification, to meet the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.