Description

Telmisartan-Hydrochlorothiazide CAS NO 485391-74-0 is a fixed-dose combination active pharmaceutical ingredient (API) used in the formulation of antihypertensive medications. This combination synergistically targets multiple pathways to provide effective blood pressure control, offering a convenient therapeutic option. It is primarily required by pharmaceutical manufacturers engaged in the development and production of solid oral dosage forms, such as tablets, for the global cardiovascular drug market.

Application

• Primary use in the manufacture of fixed-dose combination tablets for the treatment of hypertension.
• Formulation of generic pharmaceutical products containing Telmisartan and Hydrochlorothiazide.
• Research and development (R&D) of novel drug delivery systems for cardiovascular therapies.
• Production of clinical trial materials for bioequivalence and stability studies.
• As a reference standard in analytical laboratories for quality control testing.

Basic Information

Product Name	Telmisartan-Hydrochlorothiazide
CAS No.	485391-74-0
Molecular Formula	C₃₃H₃₀N₄O₂ • C₇H₈ClN₃O₄S₂
Molecular Weight	723.23 g/mol
Synonyms	Telmisartan HCTZ; Telmisartan and Hydrochlorothiazide; Micardis HCT (Brand Combination); Telmisartan/Hydrochlorothiazide Mixture; 4'-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]-2-biphenylcarboxylic acid compound with 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Telmisartan - Hydrochlorothiazide (1:1); Telmisartan Hydrochlorothiazide Combination API
EINECS	Contact for details

Quality Control

Our Telmisartan-Hydrochlorothiazide is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications typically aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, assay, and impurity profiles is provided with each batch to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.