Description

2,5-Pyrrolidinedione, 1-[(5-Azido-1-Oxopentyl)Oxy]- is a specialized heterocyclic compound featuring a reactive azido-terminated linker, making it a valuable building block for advanced synthesis. This compound matters for its utility in click chemistry and bioconjugation applications, enabling the efficient and selective formation of covalent bonds under mild conditions. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotech, and materials science industries for developing novel drug conjugates, polymers, and functionalized surfaces.

Application

• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and other biomolecules via azide-alkyne cycloaddition (CuAAC or SPAAC).
• Pharmaceutical Intermediate: Serves as a key synthon in the development of antibody-drug conjugates (ADCs) and targeted therapeutics.
• Polymer & Materials Science: Functionalizes polymer backbones or surfaces to introduce azide groups for subsequent modification, creating smart materials and hydrogels.
• Chemical Probe Synthesis: Employed to create activity-based probes (ABPs) or imaging agents for proteomics and diagnostic research.
• Crosslinking Agent: Facilitates the formation of crosslinked networks in polymer chemistry and biomaterial fabrication.
• Peptide & Protein Modification: Enables the introduction of functional handles onto peptides for structural studies or therapeutic enhancement.

Basic Information

Product Name	2,5-Pyrrolidinedione, 1-[(5-Azido-1-Oxopentyl)Oxy]-
CAS No.	478801-48-8
Molecular Formula	C9H12N4O4
Molecular Weight	240.22 g/mol
Synonyms	1-[(5-Azido-1-oxopentyl)oxy]pyrrolidine-2,5-dione; 5-Azidopentanoic Acid Succinimidyl Ester; NHS-PEG4-Azide; Azido-PEG4-NHS Ester; Succinimidyl 5-azidopentanoate; N-Hydroxysuccinimide ester of 5-azidopentanoic acid; Azido-PEG4-OSu; 5-Azidopentanoyloxy Succinimide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing lot-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.