Description

[1'-13C]2'-Deoxyguanosine Monohydrate is a stable isotope-labeled nucleoside, specifically a monohydrate form of 2'-deoxyguanosine with a carbon-13 label at the 1' position of the sugar moiety. This compound is a critical reagent in advanced biomedical research, enabling precise metabolic tracing and quantification in nucleic acid studies. It is primarily utilized by research scientists and pharmaceutical developers in the fields of metabolomics, pharmacokinetics, and drug discovery for applications such as LC-MS/MS method development and biomarker research.

Application

• Internal Standard for Mass Spectrometry: Serves as a quantitative reference standard in LC-MS and LC-MS/MS analyses of deoxyguanosine and related metabolites.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to track the incorporation and turnover of nucleotides in DNA synthesis and repair pathways.
• Biomedical Research: Essential for investigating cellular metabolism, oxidative stress (e.g., 8-oxo-dG formation), and nucleotide pool dynamics.
• Pharmaceutical Development: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies for novel nucleoside analog drugs and anticancer agents.
• Diagnostic Assay Development: Used as a calibrator or control in the development of clinical diagnostic tests for genetic disorders or cancer biomarkers.
• Stable Isotope Labeling Studies (SILS): Facilitates accurate quantification in proteomics and metabolomics by minimizing matrix effects in mass spectrometry.

Basic Information

Product Name	[1'-13C]2'-Deoxyguanosine Monohydrate
CAS No.	478511-26-1
Molecular Formula	C10H13[13C]N5O4 · H2O
Molecular Weight	307.26 g/mol (for monoisotopic unlabeled form, C10H15N5O5)
Synonyms	1'-Carbon-13 Labeled 2'-Deoxyguanosine Monohydrate
[1'-13C]-2'-Deoxyguanosine Monohydrate
2'-Deoxy[1'-13C]guanosine Monohydrate
2'-Deoxyguanosine-1'-13C Monohydrate
dG-1'-13C Monohydrate
9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl-1-13C)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one Monohydrate
Stable Isotope-Labeled Deoxyguanosine
EINECS	Contact for details

Quality Control

Every batch of [1'-13C]2'-Deoxyguanosine Monohydrate is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR (1H, 13C), HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying the isotopic enrichment (typically >99 atom % 13C), chemical purity, and confirming the absence of critical impurities. Our quality commitment ensures reliability for your most sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Water Content (KF)	5.0 - 8.0% (Theoretical for monohydrate: ~5.9%)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.