Description

[1',2',3',4',5'-13C5]2'-Deoxyadenosine Monohydrate is a stable isotope-labeled nucleoside analog, specifically a monohydrate form of deoxyadenosine with carbon-13 enrichment at five key positions. This high-purity labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway elucidation. It is primarily utilized by researchers and manufacturers in pharmaceutical development, clinical diagnostics, and metabolomics studies requiring exceptional accuracy and traceability.

Application

• Internal Standard for LC-MS/MS and GC-MS: Serves as a critical quantitative reference standard in mass spectrometry for analyzing endogenous deoxyadenosine and related metabolites in biological samples.
• Metabolic Flux Analysis (MFA): Used as a tracer to study nucleotide metabolism, DNA synthesis, and salvage pathways in cell culture and in vivo models.
• Pharmaceutical R&D: Employed in the development and validation of bioanalytical methods for antiviral and anticancer nucleoside analog drugs.
• Clinical Diagnostics: Facilitates accurate measurement of deoxyadenosine levels in diagnostic assays for metabolic disorders, such as adenosine deaminase deficiency.
• Isotope Dilution Mass Spectrometry (IDMS): Provides the gold-standard methodology for achieving high-accuracy, definitive measurements in complex matrices.
• Biochemical Research: Used in enzymatic studies and as a building block for synthesizing labeled DNA probes or primers.

Basic Information

Product Name	[1',2',3',4',5'-13C5]2'-Deoxyadenosine Monohydrate
CAS No.	478510-79-1
Molecular Formula	C1013C5H15N5O4 • H2O
Molecular Weight	272.23 g/mol (for 13C5 labeled form)
Synonyms	2'-Deoxyadenosine-13C5 monohydrate; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-13C5adenine monohydrate; dA-13C5 monohydrate; Labeled 2'-Deoxyadenosine; Adenine deoxyriboside-13C5 monohydrate; Stable Isotope-Labeled Deoxyadenosine; 13C5-2'-dA; 478510-79-1 (CAS)
EINECS	Contact for details

Quality Control

Every batch of [1',2',3',4',5'-13C5]2'-Deoxyadenosine Monohydrate is manufactured and tested under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous analytical characterization, including HPLC, NMR, and Mass Spectrometry, to confirm identity, isotopic enrichment (typically >99 atom% 13C), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom% 13C
Isotopic Purity (MS)	≥ 99% 13C5
Water Content (KF)	4.0 - 7.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.