Description

Cyclohexanecarbonyl Chloride, 3-(Trifluoromethyl)- (9Ci) CAS NO 477905-45-6 is a specialized fluorinated building block characterized by a reactive acid chloride group on a cyclohexane ring substituted with a trifluoromethyl group. This molecular architecture makes it a critical intermediate for introducing lipophilic, electron-withdrawing motifs into target molecules, which is essential for modulating the physicochemical and biological properties of advanced compounds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the cyclohexane and CF3 groups contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, leveraging the properties of the trifluoromethyl group to influence dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing characteristics such as chemical resistance, hydrophobicity, and optical clarity for specialty coatings and high-performance materials.
• Organic Synthesis & Catalysis Research: A versatile reagent for constructing complex organic frameworks in academic and industrial research, including use in cross-coupling reactions and as a substrate for developing new catalytic methodologies.
• Fluorinated Surfactant & Lubricant Precursor: Acts as an intermediate for synthesizing specialty surfactants and lubricants that require the unique surface-active and thermal properties imparted by fluorocarbon chains.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 3-(Trifluoromethyl)- (9Ci)
CAS No.	477905-45-6
Molecular Formula	C8H10ClF3O
Molecular Weight	214.61 g/mol
Synonyms	3-(Trifluoromethyl)cyclohexanecarbonyl chloride; 3-(Trifluoromethyl)cyclohexane-1-carbonyl chloride; 3-Trifluoromethylcyclohexanecarboxylic acid chloride; Cyclohexanecarbonyl chloride, 3-(trifluoromethyl)-; 1-Carboxy-3-(trifluoromethyl)cyclohexane chloride; 3-Trifluoromethyl-1-cyclohexanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 3-(Trifluoromethyl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We employ advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. Our quality system supports compliance with cGMP and ISO standards for research and commercial-scale supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 3.0%
Density (at 20°C)	~1.3 g/cm³
Refractive Index (n20D)	~1.43

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.