Description

Cyclohexanecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci) is a specialized organofluorine building block and acid chloride derivative. This compound is valued for its role in introducing the trifluoromethyl-substituted cyclohexane moiety into target molecules, a key structural feature in advanced material and pharmaceutical research. It is primarily sought by R&D chemists and process development scientists in the agrochemical and pharmaceutical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the cyclohexane ring provides conformational rigidity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, altering surface properties, chemical resistance, and thermal stability for specialty coatings and high-performance materials.
• Cross-Coupling Reactions: Acts as an electrophile in various metal-catalyzed coupling reactions (e.g., Suzuki, Negishi) to create complex, fluorinated biaryl structures.
• Peptide & Protein Research: Can be utilized as a derivatization or labeling reagent in biochemical research due to its reactive acyl chloride functionality.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 4-(Trifluoromethyl)- (9Ci)
CAS No.	477905-43-4
Molecular Formula	C8H10ClF3O
Molecular Weight	214.61 g/mol
Synonyms	4-(Trifluoromethyl)cyclohexanecarbonyl chloride; 4-(Trifluoromethyl)cyclohexanoyl chloride; 4-(Trifluoromethyl)cyclohexane-1-carbonyl chloride; trans-4-(Trifluoromethyl)cyclohexanecarbonyl chloride; cis-4-(Trifluoromethyl)cyclohexanecarbonyl chloride; p-Trifluoromethylcyclohexanecarbonyl chloride; Cyclohexanecarbonyl chloride, 4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 4-(Trifluoromethyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and meet the stringent requirements of research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture ingress. Keep away from strong bases, oxidizers, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.