Description

4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonyl Chloride is a high-purity, reactive chemical intermediate featuring a thiazole core and an acid chloride functional group. This compound is critically important for its role as a key building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used as a building block for developing advanced herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the creation of activity-based probes and labeled compounds for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-purity, complex heterocyclic intermediates.

Basic Information

Product Name	4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonyl Chloride
CAS No.	477291-09-1
Molecular Formula	C12H7ClF3NOS
Molecular Weight	305.70 g/mol
Synonyms	5-Carbonyl chloride-4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole; 2-(4-Trifluoromethylphenyl)-4-methyl-1,3-thiazole-5-carbonyl chloride; 4-Methyl-2-(4-trifluoromethylphenyl)thiazole-5-carbonyl chloride; 4-Methyl-2-(α,α,α-trifluoro-p-tolyl)thiazole-5-carbonyl chloride; Thiazole-5-carbonyl chloride, 4-methyl-2-[4-(trifluoromethyl)phenyl]-; CAS 477291-09-1
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.