Description

(2-Bromo-4,5-Difluorophenyl)Methanol is a versatile fluorinated and brominated benzyl alcohol derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated aromatic structure makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluorophenyl moiety can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic components in electronic materials, contributing to improved performance in display and lighting technologies.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Ligand & Catalyst Development: Utilized in the synthesis of novel chiral or bidentate ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Acts as a monomer or modifier for introducing halogenated aromatic units into high-performance polymers and resins.

Basic Information

Product Name	(2-Bromo-4,5-Difluorophenyl)Methanol
CAS No.	476620-55-0
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	2-Bromo-4,5-difluorobenzyl alcohol; (2-Bromo-4,5-difluorophenyl)methanol; 4,5-Difluoro-2-bromobenzyl alcohol; 1-Bromo-2,3-difluoro-4-(hydroxymethyl)benzene; α-Hydroxy-2-bromo-4,5-difluorotoluene; Benzenemethanol, 2-bromo-4,5-difluoro-; (2-Br-4,5-F2-Ph)CH2OH
EINECS	Contact for details

Quality Control

Our (2-Bromo-4,5-Difluorophenyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.