Description

4-Amino-3-(1-Naphthylmethyl)-1H-Pyrazolo[3,4-D]Pyrimidine-1-(β-D-Ribofuranosyl-5’-Triphosphate) is a sophisticated nucleotide analog with significant biochemical and pharmacological research applications. This compound matters as a key building block for the development of novel enzyme inhibitors and probes for studying cellular signaling pathways, particularly those involving kinases and ATP-binding proteins. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in drug discovery, molecular biology, and medicinal chemistry.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study kinase activity and nucleotide-dependent processes.
• Medicinal Chemistry & Drug Discovery: Serves as a critical precursor or intermediate in the synthesis of potential therapeutic agents targeting cancer, inflammatory diseases, and metabolic disorders.
• Molecular Probe Development: Utilized to create labeled or modified probes for investigating protein-ligand interactions and cellular metabolism.
• Nucleotide Analog Synthesis: Acts as a specialized building block for synthesizing novel modified nucleotides for antisense, RNAi, or diagnostic applications.
• Academic Research: Employed in university and institutional labs for fundamental studies in biochemistry, enzymology, and structural biology.
• Pharmaceutical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4-Amino-3-(1-Naphthylmethyl)-1H-Pyrazolo[3,4-D]Pyrimidine-1-(β-D-Ribofuranosyl-5’-Triphosphate)
CAS No.	476371-81-0
Molecular Formula	C26H27N6O14P3
Molecular Weight	764.45 g/mol
Synonyms	4-Amino-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl β-D-ribofuranosyl 5'-triphosphate; 1-(5'-Triphospho-β-D-ribofuranosyl)-4-amino-3-(1-naphthylmethyl)pyrazolo[3,4-d]pyrimidine; Naphthylmethyl-pyrazolopyrimidine riboside triphosphate; ATP analog with naphthylmethyl-pyrazolopyrimidine base; Modified nucleotide triphosphate; Kinase inhibitor precursor; Research nucleotide 476371-81-0
EINECS	Contact for details

Quality Control

Our production of this advanced nucleotide analog adheres to strict quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment. We support compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.