Description

2-(Methylthio)Adenosine 5'-Diphosphate Trisodium Salt is a chemically modified nucleotide analog of adenosine diphosphate (ADP). This compound is a critical biochemical tool for studying purinergic signaling pathways, particularly as a potent and selective agonist for the P2Y1 receptor subtype. It is essential for researchers and developers in pharmaceutical discovery, biochemical research, and diagnostic assay development who require high-purity, well-characterized ligands for receptor characterization and signal transduction studies.

Application

• P2Y1 Receptor Research: Primary use as a selective agonist in pharmacological studies to investigate the role of P2Y1 receptors in cardiovascular, neurological, and immune system functions.
• Drug Discovery & Screening: A key reference standard and tool compound in high-throughput screening (HTS) assays to identify and characterize novel P2Y receptor modulators and antagonists.
• Biochemical Pathway Analysis: Used in cell-based and enzymatic assays to elucidate ADP-mediated signaling cascades, platelet aggregation studies, and calcium mobilization experiments.
• Diagnostic Development: Employed in the development of diagnostic kits and assays targeting purinergic receptor activity for research and clinical applications.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes focused on molecular pharmacology, cell biology, and neurochemistry.
• GMP Intermediate: Serves as a potential synthetic intermediate or reference standard in the GMP-compliant production of advanced therapeutic agents.

Basic Information

Product Name	2-(Methylthio)Adenosine 5'-Diphosphate Trisodium Salt
CAS No.	475193-31-8
Molecular Formula	C11H14N5O10P2S · 3Na
Molecular Weight	573.17 g/mol (anhydrous basis)
Synonyms	2-Methylthio-ADP trisodium salt; 2-MeS-ADP Na3; Adenosine-5'-diphosphate, 2-(methylthio)-, trisodium salt; 2-(Methylthio)adenosine 5'-(trihydrogen diphosphate) trisodium salt; P2Y1 receptor agonist; 2-MeSADP trisodium; MRS 2365 (related trisodium form); 2-(Methylthio)-ADP Na3
EINECS	Contact for details

Quality Control

Our 2-(Methylthio)ADP Trisodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, employing techniques such as HPLC, NMR, and mass spectrometry for characterization. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤5.0%
pH (1% Solution)	6.0 - 8.0
Biological Activity	Confirmed via P2Y1 receptor assay (Data on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.