Description

Tivozanib is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. This compound is a critical active pharmaceutical ingredient (API) for targeted cancer therapy, specifically designed to inhibit tumor angiogenesis. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of innovative oncology treatments. Tivozanib CAS NO 475108-18-0 represents a high-value component in the pipeline of next-generation anti-cancer therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulated anti-cancer drugs.
• Oncology Research: A key reference standard and tool compound for studying VEGFR signaling pathways and angiogenesis inhibition in preclinical models.
• Drug Development: Utilized in the synthesis and process development of novel tyrosine kinase inhibitor (TKI) therapies.
• Clinical Trial Material (CTM): Sourced for the manufacture of investigational medicinal products for clinical studies.
• Biochemical Assays: Employed as a selective inhibitor in high-throughput screening and enzymatic assays to evaluate drug efficacy and mechanism of action.

Basic Information

Product Name	Tivozanib
CAS No.	475108-18-0
Molecular Formula	C22H19ClN4O5
Molecular Weight	454.86 g/mol
Synonyms	AV-951; KRN-951; 1-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea; Tivozanib Hydrochloride (salt form); Fotivda (brand name); VEGFR Inhibitor; Quinazoline derivative
EINECS	Contact for details

Quality Control

Our Tivozanib is manufactured under strict quality systems to meet the exacting standards required for pharmaceutical intermediates and APIs. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) is provided with every shipment, detailing compliance with agreed specifications. We support development and commercial projects requiring adherence to cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.