Description

3-[(5,6-Dimethylthieno[2,3-D]Pyrimidin-1-Ium-4-Yl)Amino]Benzoic Acid Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive acid chloride functional group. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, biotechnology, and fine chemical sectors seeking to develop new drug candidates with enhanced efficacy.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex heterocyclic compounds and targeted small molecule drugs.
• Kinase Inhibitor Development: Serves as a crucial precursor in the research and production of protein kinase inhibitors for oncology and inflammatory diseases.
• Bioconjugation & Probe Synthesis: Used in medicinal chemistry to create fluorescent probes or affinity labels for biological target identification and validation.
• Academic & Industrial R&D: Employed in research institutions and corporate R&D centers for exploring new chemical entities and structure-activity relationships (SAR).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production under cGMP conditions.

Basic Information

Product Name	3-[(5,6-Dimethylthieno[2,3-D]Pyrimidin-1-Ium-4-Yl)Amino]Benzoic Acid Chloride
CAS No.	474263-21-3
Molecular Formula	C17H14ClN3O2S
Molecular Weight	359.83 g/mol
Synonyms	3-[(5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)amino]benzoyl chloride; 4-((3-(Chlorocarbonyl)phenyl)amino)-5,6-dimethylthieno[2,3-d]pyrimidin-1-ium; Benzoic acid, 3-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)amino]-, chloride; 3-((5,6-Dimethylthieno[2,3-d]pyrimidin-4-yl)amino)benzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 3-[(5,6-Dimethylthieno[2,3-D]Pyrimidin-1-Ium-4-Yl)Amino]Benzoic Acid Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced pharmaceutical synthesis. All materials are subjected to comprehensive analytical characterization, including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.