Description

3-o-Methyl 6-Hydroxy-17β-Estradiol CAS NO 473882-84-7 is a high-purity, synthetically derived estrogen derivative, specifically a methylated and hydroxylated analog of 17β-estradiol. This compound is of significant value in pharmaceutical research and development, serving as a critical intermediate or reference standard for the synthesis of novel steroidal drugs and for metabolic studies. It is primarily required by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in endocrinology, oncology, and hormone replacement therapy (HRT) research.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathway of advanced steroidal active pharmaceutical ingredients (APIs) and prodrugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) of related estrogenic compounds via HPLC, LC-MS, or GC-MS.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate estrogen receptor (ER) binding affinity, selectivity, and metabolic pathways.
• Metabolite Studies: Serves as a model compound or synthetic target for studying the metabolism of endogenous and exogenous estrogens.
• Academic Research: Utilized in university and institutional labs for fundamental research in steroid chemistry and endocrinology.

Basic Information

Product Name	3-o-Methyl 6-Hydroxy-17β-Estradiol
CAS No.	473882-84-7
Molecular Formula	C19H26O3
Molecular Weight	302.41 g/mol
Synonyms	3-Methoxyestra-1,3,5(10)-triene-6,17β-diol; 6-Hydroxy-3-methoxyestra-1,3,5(10)-trien-17β-ol; 3-Methoxy-6-hydroxyestradiol; 3-O-Methyl-6-hydroxyestradiol; 17β-Estradiol 3-methyl ether 6-ol; 6-Hydroxy-3-methoxy-17β-estradiol; Estra-1,3,5(10)-triene-3,6,17-triol, 3-methyl ether
EINECS	Contact for details

Quality Control

Our 3-o-Methyl 6-Hydroxy-17β-Estradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.