Description

2'-O-(2-Methoxyethyl)Guanosine is a chemically modified nucleoside, specifically a guanosine derivative with a 2'-O-methoxyethyl (2'-MOE) substitution. This modification is critical for enhancing the binding affinity and nuclease resistance of oligonucleotides, making it a foundational building block in advanced therapeutic development. It is primarily required by pharmaceutical R&D departments and biotechnology companies engaged in the synthesis of antisense oligonucleotides and other nucleic acid-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite monomer for constructing therapeutic oligonucleotides with improved stability and target engagement.
• Research & Development: Used in academic and industrial labs for studying RNA interference (RNAi), gene expression, and nucleic acid chemistry.
• Therapeutic Agent Development: Serves as a critical raw material in the production of investigational new drugs (INDs) targeting genetic disorders, cancers, and viral infections.
• Diagnostic Probe Manufacture: Incorporated into probes and primers for high-specificity molecular diagnostics and detection assays.
• Bioconjugation and Labeling: Acts as a starting point for creating labeled nucleotides used in imaging and tracking studies.

Basic Information

Product Name	2'-O-(2-Methoxyethyl)Guanosine
CAS No.	473278-54-5
Molecular Formula	C13H19N5O6
Molecular Weight	341.32 g/mol
Synonyms	2'-O-MOE-Guanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 2'-MOE-Guanosine; Guanosine, 2'-O-(2-methoxyethyl)-; 2'-(2-Methoxyethoxy)guanosine
EINECS	Contact for details

Quality Control

Our 2'-O-(2-Methoxyethyl)Guanosine is manufactured under strict quality systems suitable for pharmaceutical research applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, ensuring traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.