Description

Cyclopropanecarbonyl Chloride, 2,2-Difluoro-3-Methyl- (9Ci) is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its core value lies in the reactive acid chloride functional group, which enables efficient coupling reactions to introduce the unique 2,2-difluoro-3-methylcyclopropyl moiety into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, where the difluorocyclopropyl group can improve stability and bioactivity.
• Material Science Research: Serves as a precursor for specialty monomers or ligands used in advanced polymers and catalysts.
• Fluorine Chemistry: An essential reagent for studying structure-activity relationships (SAR) by introducing fluorinated cyclopropane motifs into organic frameworks.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring this precise fluorinated scaffold.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2,2-Difluoro-3-Methyl- (9Ci)
CAS No.	473237-10-4
Molecular Formula	C5H5ClF2O
Molecular Weight	154.54 g/mol
Synonyms	2,2-Difluoro-3-methylcyclopropanecarbonyl chloride; 3-Methyl-2,2-difluorocyclopropanecarboxylic acid chloride; 2,2-Difluoro-3-methylcyclopropanecarboxylic acid chloride; 2,2-Difluoro-3-methyl-1-cyclopropanecarbonyl chloride; (2,2-Difluoro-3-methylcyclopropyl)carbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2,2-Difluoro-3-Methyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, it should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for optimal shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.