Description

8-Bromo-2-Iodoadenosine is a halogenated nucleoside derivative of significant interest in medicinal chemistry and biochemical research. This compound serves as a versatile building block for the synthesis of modified nucleotides and adenosine receptor ligands. It is primarily utilized by researchers and pharmaceutical developers in the fields of nucleic acid chemistry, drug discovery, and molecular biology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel adenosine receptor agonists and antagonists for therapeutic development.
• Biochemical Probe Synthesis: Used to create labeled or modified nucleotides for studying enzyme mechanisms, such as those of kinases and polymerases.
• Antiviral & Anticancer Research: Serves as a scaffold for developing nucleoside analogs with potential antiviral or anticancer activity.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse adenosine derivatives.
• Molecular Biology Tool: Can be incorporated into oligonucleotides to modify their properties or to serve as a site for further chemical conjugation.
• Chemical Biology Studies: Employed in the development of activity-based probes or photoaffinity labels for target identification.

Basic Information

Product Name	8-Bromo-2-Iodoadenosine
CAS No.	457060-99-0
Molecular Formula	C10H10BrIN5O4
Molecular Weight	471.03 g/mol
Synonyms	8-Bromo-2-iodoadenosine; 9-β-D-Ribofuranosyl-8-bromo-2-iodo-9H-purin-6-amine; 2-Iodo-8-bromoadenosine; Adenosine, 8-bromo-2-iodo-; 8-Br-2-I-Ado
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-Iodoadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.