Description

3'-Deoxy-2'-Thiouridine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical research and development. Its unique structure, featuring a sulfur substitution and deoxy modification, makes it a critical intermediate for synthesizing novel therapeutic agents, particularly in antiviral and anticancer drug discovery. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality raw materials for their most demanding applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Research: Used in the development of therapeutic agents targeting viral polymerases and replication mechanisms.
• Oligonucleotide Synthesis: Serves as a modified monomer for creating thio-modified RNA or DNA strands to enhance stability and study structure-activity relationships.
• Biochemical Research: Employed as a probe to study enzyme mechanisms, nucleic acid metabolism, and cellular processes involving nucleosides.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Diagnostic Reagent Development: Potential use in creating labeled probes or components for diagnostic assays.

Basic Information

Product Name	3'-Deoxy-2'-Thiouridine
CAS No.	455951-69-6
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	2-Thio-3'-deoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4(3H)-one; 3'-Deoxy-2-thiouridine; 2-Thiouridine, 3'-deoxy-; 2-Thio-3'-deoxyuridine; 4(1H)-Pyrimidinone, 1-[4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2-thioxo-; 3'-d-2-Thiouridine
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-2'-Thiouridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.