Description

Motesanib CAS NO 453562-69-1 is a potent and selective small-molecule inhibitor targeting receptor tyrosine kinases, including VEGFR, PDGFR, and Kit. This compound is a critical research tool and pharmaceutical intermediate for developing novel anti-angiogenic and anti-tumor therapies. It is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors focused on oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of targeted cancer therapies.
• Kinase Inhibition Studies: Used extensively in biochemical and cellular assays to study the role of VEGFR, PDGFR, and Kit signaling pathways in angiogenesis and tumor growth.
• Preclinical Drug Evaluation: Employed in animal models to assess the efficacy, pharmacokinetics, and safety profile of anti-angiogenic compounds.
• Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex kinase inhibitor analogs and derivatives.
• Academic Research: Utilized in university and institutional labs for fundamental research into tyrosine kinase function and cancer biology.

Basic Information

Product Name	Motesanib
CAS No.	453562-69-1
Molecular Formula	C₂₂H₁₈N₄O
Molecular Weight	354.41 g/mol
Synonyms	AMG 706; N-(2,3-Dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide; Motesanib diphosphate; AMG-706; Motesanib (AMG 706)
EINECS	Contact for details

Quality Control

Our Motesanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.