Description

2-Propenamide, n-[4-[(3-Chloro-4-Fluorophenyl)Amino]-7-[3-Methyl-3-(4-Methyl-1-Piperazinyl)-1-Butyn-1-Yl]-6-Quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) is a high-purity, non-salt form pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound matters as a critical building block in the synthesis of targeted kinase inhibitors, offering researchers and manufacturers a reliable starting point for complex drug development. It is primarily needed by pharmaceutical R&D laboratories and API manufacturers focused on oncology and other therapeutic areas requiring precise molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel quinazoline-based kinase inhibitor candidates.
• Oncology Research: Used in the discovery and development of targeted cancer therapies, particularly those aimed at specific tyrosine kinase pathways.
• Active Pharmaceutical Ingredient (API) Development: Employed in process chemistry for scaling up the production of investigational new drugs.
• Biochemical Research: Acts as a tool compound for studying enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	2-Propenamide, n-[4-[(3-Chloro-4-Fluorophenyl)Amino]-7-[3-Methyl-3-(4-Methyl-1-Piperazinyl)-1-Butyn-1-Yl]-6-Quinazolinyl]-, 4-Methylbenzenesulfonate (1:2)
CAS No.	451493-31-5
Molecular Formula	C34H34ClFN6O2 · 2C7H8O3S
Molecular Weight	Contact for details
Synonyms	N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide ditosylate; Afatinib ditosylate; BIBW 2992 ditosylate; Afatinib dimethanesulfonate (common alias); Tovok intermediate; Gilotrif intermediate; Giotrif intermediate; Tyrosine kinase inhibitor intermediate
EINECS	Contact for details

Quality Control

Our 2-Propenamide, n-[4-[(3-Chloro-4-Fluorophenyl)Amino]-7-[3-Methyl-3-(4-Methyl-1-Piperazinyl)-1-Butyn-1-Yl]-6-Quinazolinyl]-, 4-Methylbenzenesulfonate (1:2) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are available upon request. Production can be aligned with cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.