Description

3,5-Bis(Trifluoromethyl)Phenylthioethanol is a high-value fluorinated aromatic building block characterized by its unique combination of a thioethanol linker and electron-withdrawing trifluoromethyl groups. This compound matters for its role in facilitating the synthesis of complex molecules where the introduction of lipophilicity, metabolic stability, and specific steric profiles is critical. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and advanced material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the trifluoromethyl groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into monomers for specialty polymers, liquid crystals, and organic electronic materials to modify solubility and electronic properties.
• Chemical Biology Probes: Utilized in the development of fluorescent tags and molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenylthioethanol
CAS No.	450409-97-9
Molecular Formula	C10H8F6OS
Molecular Weight	290.22 g/mol
Synonyms	2-[3,5-Bis(trifluoromethyl)phenyl]thio]ethanol; 2-((3,5-Bis(trifluoromethyl)phenyl)thio)ethan-1-ol; 3,5-Bis(trifluoromethyl)benzenethiol, 2-hydroxyethyl ether; 3,5-Bis(trifluoromethyl)phenyl 2-hydroxyethyl sulfide; (3,5-Bis(trifluoromethyl)phenyl)(2-hydroxyethyl)sulfide
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Phenylthioethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.