Description

2'-Deoxyadenosine-1'-13C Monohydrate is a stable isotope-labeled nucleoside derivative, where the carbon-13 isotope is specifically incorporated at the 1' position of the deoxyribose sugar. This precise labeling is critical for advanced analytical applications, providing a non-radioactive tracer for metabolic and pharmacokinetic studies. It is an essential building block for researchers and manufacturers in the fields of nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and stable isotope probing, as well as for the synthesis of labeled oligonucleotides and nucleic acid analogs.

Application

• Biomedical Research & NMR Spectroscopy: Used as an internal standard and tracer for studying the metabolism, biosynthesis, and catabolism of nucleic acids and related compounds.
• Mass Spectrometry (MS) & Liquid Chromatography-Mass Spectrometry (LC-MS): Serves as a critical reference standard for the accurate quantification of deoxyadenosine and its metabolites in complex biological matrices.
• Stable Isotope Probing (SIP): Employed in environmental and microbial ecology to track the incorporation of labeled substrates into DNA, enabling the study of active microbial communities.
• Pharmaceutical Development: Utilized in the synthesis of carbon-13 labeled antiviral or anticancer nucleoside analogs for drug metabolism and pharmacokinetics (DMPK) studies.
• Diagnostic Reagent Manufacturing: Acts as a key raw material in producing high-precision diagnostic kits and assays that require isotopically labeled components.
• Academic & Contract Research: Fundamental reagent for universities and CROs conducting cutting-edge research in biochemistry, molecular biology, and chemical biology.

Basic Information

Product Name	2'-Deoxyadenosine-1'-13C Monohydrate
CAS No.	446276-63-7
Molecular Formula	C10H13N5O4·H2O (with 13C at position 1')
Molecular Weight	Contact for details
Synonyms	1'-13C-2'-Deoxyadenosine Monohydrate; 2'-Deoxy-1'-13C-adenosine Monohydrate; 9-(2-Deoxy-1-13C-β-D-erythro-pentofuranosyl)adenine Monohydrate; 13C-Labeled Deoxyadenosine; Adenine Deoxyriboside-1'-13C Monohydrate; dA-1'-13C Monohydrate; Isotope-Labeled Nucleoside; [1'-13C]-2'-Deoxyadenosine Monohydrate
EINECS	Contact for details

Quality Control

Every batch of 2'-Deoxyadenosine-1'-13C Monohydrate is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR and HPLC-MS. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing parameters such as assay, isotopic enrichment, and impurity profile. Our quality commitment ensures the material meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent degradation from moisture and light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C at 1' position)
Assay (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Water Content (KF)	4.0% - 7.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.