Description

Pazopanib CAS NO 444731-52-6 is a potent and selective multi-targeted receptor tyrosine kinase inhibitor. This compound is of critical importance in pharmaceutical research and development, primarily for its role in targeting specific pathways involved in cell proliferation and angiogenesis. It is an essential active pharmaceutical ingredient (API) and key intermediate for researchers and manufacturers in the oncology therapeutics sector, particularly for the development of treatments for advanced renal cell carcinoma and soft tissue sarcoma.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key therapeutic agent in formulated anti-cancer medications.
• Oncology Research: Critical tool for in vitro and in vivo studies targeting VEGFR, PDGFR, and c-Kit signaling pathways.
• Pharmaceutical Intermediates: Serves as a high-purity building block in the synthesis of more complex drug formulations.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug products.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during drug discovery.
• Generic Drug Manufacturing: Sourced by manufacturers producing bioequivalent versions of branded pazopanib hydrochloride tablets.

Basic Information

Product Name	Pazopanib
CAS No.	444731-52-6
Molecular Formula	C21H23N7O2S
Molecular Weight	437.52 g/mol
Synonyms	Pazopanib Base; Pazopanib (Free Base); GW786034; 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide; Votrient (Trade Name for Hydrochloride Salt); Pazopanib Hydrochloride (Salt Form); Pazopanib HCl
EINECS	Contact for details

Quality Control

Our Pazopanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with ICH guidelines and current Good Manufacturing Practice (cGMP) principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.