Description

7-Iodo-7-Deaza-D-Guanosine is a chemically modified nucleoside analog, specifically engineered for advanced research and development applications. This compound is a critical building block in the synthesis of oligonucleotides, offering unique properties for modulating nucleic acid interactions and stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors. Its precise structure makes it a valuable tool for probing biological mechanisms and developing novel therapeutic agents.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified antisense oligonucleotides (ASOs) and siRNA.
• Medicinal Chemistry: Serves as a crucial intermediate in the research and development of nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a probe to study enzyme mechanisms, particularly those involving polymerases and nucleoside kinases.
• Diagnostic Development: Incorporated into nucleic acid probes and primers to enhance specificity and detection sensitivity in molecular assays.
• Structural Biology: Employed in X-ray crystallography and NMR studies to investigate nucleic acid structure and ligand binding.
• Labeling and Tracing: The iodine moiety allows for potential radiolabeling (with I-125) for tracking and imaging studies in biological systems.

Basic Information

Product Name	7-Iodo-7-Deaza-D-Guanosine
CAS No.	444020-71-7
Molecular Formula	C11H12IN5O4
Molecular Weight	405.15 g/mol
Synonyms	7-Iodo-7-deazaguanosine; 7-Iodo-tubercidin; 7-Deaza-7-iodoguanosine; 4-Amino-7-iodo-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; 7-Iodo-7H-pyrrolo[2,3-d]pyrimidin-4-amine riboside
EINECS	Contact for details

Quality Control

Our 7-Iodo-7-Deaza-D-Guanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.