Description

3'-Deoxy-3'--C-Methylguanosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in nucleoside-based drug discovery. The precise structural modification at the 3'-position offers unique properties for targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation antiviral medications, particularly for RNA virus targets.
• Anticancer Research: Investigated for its potential as a prodrug or direct agent in oncology research due to its mechanism of action on nucleotide metabolism.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase function and nucleotide incorporation.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies in drug candidate pipelines.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex nucleoside analogs under GMP conditions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	3'-Deoxy-3'--C-Methylguanosine
CAS No.	444020-69-3
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	3'-Deoxy-3'-C-methylguanosine; 3'-C-Methylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 3'-Methyl-3'-deoxyguanosine; Guanosine, 3'-deoxy-3'-C-methyl-; 3'-C-Me-Guo
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'--C-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets stringent research and pharmaceutical-grade standards. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.