Description

3'-Deoxy-3'-α-C-Methyluridine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly in the development of nucleoside reverse transcriptase inhibitors (NRTIs). It is primarily sought after by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of high-value active pharmaceutical ingredients (APIs). The precise structural modification at the 3'-position offers unique properties for probing biological mechanisms and developing targeted drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleic acid metabolism.
• Antiviral Agent Development: Critical precursor for the research and production of novel nucleoside analogs targeting viruses such as Hepatitis C Virus (HCV) and other RNA viruses.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of therapeutic nucleosides.
• Process Chemistry: Serves as a high-purity starting material for scaling up GMP-compliant synthesis routes for clinical trial materials.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation of related substances.

Basic Information

Product Name	3'-Deoxy-3'-α-C-Methyluridine
CAS No.	444020-64-8
Molecular Formula	C11H16N2O6
Molecular Weight	272.25 g/mol
Synonyms	3'-Deoxy-3'-C-methyluridine; 3'-C-Methyl-3'-deoxyuridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-α-C-Methyluridine; β-D-3'-Deoxy-3'-C-methyluridine; 2',3'-Dideoxy-3'-C-methyluridine (incorrect but common alias); Uridine, 3'-deoxy-3'-C-methyl-
EINECS	Contact for details

Quality Control

Our 3'-Deoxy-3'-α-C-Methyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.