Description

3,4,5-Trifluorophenacyl Bromide is a high-value fluorinated organic bromide building block, essential for introducing the phenacyl moiety into complex molecular architectures. Its strategic importance lies in its role as a versatile electrophile and synthon for the development of advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions, nucleophilic substitutions, and as a precursor to various heterocycles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring a trifluoromethylphenyl or phenacyl functional group.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the creation of fluorinated monomers and polymers for specialty plastics, coatings, and electronic materials.
• Cross-Coupling Reactions: Acts as an effective electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleophilic Substitution: The bromine atom is readily displaced by various nucleophiles (e.g., amines, thiols, alkoxides) to create diverse chemical linkages.

Basic Information

Product Name	3,4,5-Trifluorophenacyl Bromide
CAS No.	443914-94-1
Molecular Formula	C8H4BrF3O
Molecular Weight	245.02 g/mol
Synonyms	2-Bromo-1-(3,4,5-trifluorophenyl)ethan-1-one; 3,4,5-Trifluorophenacyl bromide; 1-(3,4,5-Trifluorophenyl)-2-bromoethanone; α-Bromo-3,4,5-trifluoroacetophenone; 2-Bromo-3',4',5'-trifluoroacetophenone; 3,4,5-Trifluoro-ω-bromoacetophenone; (3,4,5-Trifluorophenyl)-2-bromoethanone
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenacyl Bromide is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.