Description

Vandetanib CAS NO 443913-73-3 is a potent and selective small-molecule inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases. This compound is of critical importance in pharmaceutical research and development, primarily serving as a key active pharmaceutical ingredient (API). It is essential for organizations engaged in the development, formulation, and commercial manufacturing of targeted cancer therapeutics.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of targeted oncology drugs.
• Research and Development of novel therapeutic agents for thyroid cancer, non-small cell lung cancer, and other solid tumors.
• Pre-clinical and clinical pharmacology and toxicology studies to evaluate drug efficacy and safety profiles.
• Used as a reference standard in analytical laboratories for quality control and method validation.
• Intermediate in the synthesis of more complex drug molecules or prodrugs.
• Biochemical research tool for studying VEGFR and EGFR signaling pathways in cellular models.

Basic Information

Product Name	Vandetanib
CAS No.	443913-73-3
Molecular Formula	C22H24BrF2N4O2
Molecular Weight	494.35 g/mol
Synonyms	ZD6474; Zactima; Vandetanib free base; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; 4-(4-Bromo-2-fluorophenylamino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; AZD-6474
EINECS	Contact for details

Quality Control

Our Vandetanib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.