Description

Jnj-7706621 is a high-purity, small molecule chemical compound identified by CAS number 443797-96-4. This compound is valued in research and development for its role as a potent and selective inhibitor of key cell cycle kinases, specifically targeting Aurora kinases and VEGFR2. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology and anti-angiogenesis research. The material is supplied with a focus on consistent quality and reliable documentation to support critical preclinical studies.

Application

• Biochemical Research: Used as a selective tool compound to study the biological functions and signaling pathways of Aurora A, Aurora B, and VEGFR2 kinases.
• Oncology Drug Discovery: Serves as a key reference standard and starting point in the development of novel anti-cancer therapeutics targeting cell cycle progression and tumor angiogenesis.
• Mechanistic Studies: Employed in in vitro and cellular assays to investigate mechanisms of mitotic regulation, chromosomal segregation, and endothelial cell proliferation.
• High-Throughput Screening (HTS): Utilized as a control or validation compound in screening campaigns to identify new kinase inhibitors.
• Pharmacology Profiling: Applied in selectivity panels to assess the off-target effects of new chemical entities against a broad spectrum of kinases.
• Academic Research: Supports fundamental research in cell biology, providing insights into mitosis, cytokinesis, and vascular development.

Basic Information

Item	Details
Product Name	Jnj-7706621
CAS No.	443797-96-4
Molecular Formula	C₂₁H₂₀FN₅O₃
Molecular Weight	409.41 g/mol
Synonyms	1-Cyclopropyl-3-[3-[5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl]-5-(1H-pyrazol-4-yl)pyrazol-1-yl]propan-1-one; JNJ-7706621; VX-680 analog; Aurora Kinase Inhibitor VIII; ABT-348 analog; Benzamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-2-pyrimidinyl]amino]phenyl]-; Research Compound 7706621
EINECS	Contact for details

Quality Control

Every batch of Jnj-7706621 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our standard material meets a typical purity specification of ≥98% (by HPLC), suitable for research applications. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact results for all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C (59-77°F). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.