Description

5-Bromo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate in the creation of novel therapeutic agents, particularly antiviral and anticancer candidates. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and oligonucleotides.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of potential therapeutics targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a precursor in the design of nucleotide analogs that may interfere with cancer cell proliferation.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate nucleic acid metabolism and related pathways.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for diagnostic applications and basic research.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug-like properties.

Basic Information

Product Name	5-Bromo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine
CAS No.	443642-47-5
Molecular Formula	C₁₂H₁₅BrN₄O₄
Molecular Weight	359.18 g/mol
Synonyms	4-Amino-5-bromo-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-7H-pyrrolo[2,3-d]pyrimidine; 5-Bromo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; 2'-C-Methyl-4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidine ribonucleoside; 4-Amino-5-bromo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 5-Br-2'-C-Me-4-NH2-7-deaza-adenosine analog
EINECS	Contact for details

Quality Control

Our 5-Bromo-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality control protocols are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.