Description

7-Deaza-2'-C-Methyladenosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and a key intermediate in the synthesis of novel antiviral and anticancer therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery programs targeting viral polymerases and related enzymes. The high-purity material is essential for ensuring the efficacy and reproducibility of preclinical studies.

Application

• Antiviral Drug Discovery: A key intermediate in the synthesis of nucleotide analogs targeting RNA-dependent RNA polymerases (RdRp) of viruses like Hepatitis C Virus (HCV).
• Oncology Research: Investigated as a precursor for prodrugs designed to inhibit aberrant cellular proliferation and tumor growth.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide recognition.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Nucleoside Chemistry: Employed in the development of modified oligonucleotides for antisense or siRNA therapeutic applications.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	7-Deaza-2'-C-Methyladenosine
CAS No.	443642-29-3
Molecular Formula	C12H16N6O4
Molecular Weight	308.30 g/mol
Synonyms	2'-C-Methyl-7-deazaadenosine; 7-Deaza-2'-C-methyladenosine; 2'-C-Methyl-7-azaadenosine; 4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-7H-pyrrolo[2,3-d]pyrimidine; 2'-C-Me-7-deaza-Ado; 2'-Methyl-7-deazaadenosine
EINECS	Contact for details

Quality Control

Our 7-Deaza-2'-C-Methyladenosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.