Description

p-[[[1-[(6-Amino-9H-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]-Phosphonic Acid is a high-purity, nucleoside-derived phosphonate compound of significant interest in advanced pharmaceutical research and development. This molecule is valued for its role as a key synthetic intermediate or potential active pharmaceutical ingredient (API) precursor in the design of novel therapeutics. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of antiviral agents, nucleotide analogs, and other targeted small-molecule drugs. The compound's unique structure, featuring a cyclopropyl linker and a phosphonic acid group, offers specific reactivity and binding properties critical for modern medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nucleotide and nucleoside analog drugs.
• Antiviral Drug Research: Investigated as a precursor for potential therapeutic agents targeting viral polymerases and replication mechanisms.
• Medicinal Chemistry & Lead Optimization: Used in structure-activity relationship (SAR) studies to modify pharmacokinetic and pharmacodynamic properties of lead compounds.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to purine metabolism and signaling pathways.
• Pre-clinical Development: Supplied in development quantities for formulation studies, stability testing, and toxicology assessments.
• Custom Synthesis & Contract Manufacturing: Provided as a starting material for custom synthesis projects requiring high-purity, complex organic molecules.

Basic Information

Product Name	p-[[[1-[(6-Amino-9H-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]-Phosphonic Acid
CAS No.	441785-21-3
Molecular Formula	C11H14N5O4P
Molecular Weight	311.23 g/mol
Synonyms	9H-Purin-6-amine, 9-[[1-[[(4-phosphonophenyl)methoxy]methyl]cyclopropyl]methyl]-; (4-((((1-((6-Amino-9H-purin-9-yl)methyl)cyclopropyl)oxy)methyl)phenyl)phosphonic acid; Adenine cyclopropyl phosphonate derivative; p-Phosphonomethylbenzyloxycyclopropylmethyladenine; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of p-[[[1-[(6-Amino-9H-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]-Phosphonic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results and methods is provided with each shipment. We support development with custom purity grades and can provide material suitable for pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Purity (HPLC, Anhydrous Basis)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.