Description

5'-o-Levulinoyl-Thymidine is a key nucleoside derivative and a vital building block in organic synthesis and pharmaceutical research. This compound is essential for the controlled synthesis and modification of oligonucleotides, enabling the development of advanced therapeutic agents and diagnostic tools. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for applications in prodrug development, antisense technology, and nucleotide chemistry.

Application

• Oligonucleotide Synthesis: A crucial protected intermediate for the solid-phase synthesis of DNA and RNA sequences.
• Prodrug Development: Used in the design and synthesis of nucleoside prodrugs for antiviral and anticancer therapies.
• Antisense & siRNA Research: Serves as a modified building block for creating research-grade antisense oligonucleotides and small interfering RNA (siRNA).
• Bioconjugation & Labeling: The levulinoyl group provides a handle for selective chemical conjugation and labeling of biomolecules.
• Pharmaceutical Intermediates: An important precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Employed in the creation of probes for studying enzyme mechanisms and nucleic acid interactions.

Basic Information

Product Name	5'-o-Levulinoyl-Thymidine
CAS No.	440327-46-8
Molecular Formula	C16H20N2O7
Molecular Weight	352.34 g/mol
Synonyms	5'-O-(4-Oxopentanoyl)thymidine; Thymidine 5'-levulinate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione 5'-(4-oxopentanoate); 5'-Levulinylthymidine; Levulinic acid thymidine-5'-yl ester; 2'-Deoxythymidine 5'-levulinate; 5'-O-Levulinoyl-2'-deoxythymidine
EINECS	Contact for details

Quality Control

Our 5'-o-Levulinoyl-Thymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.