Description

5-Bromo-3'-Deoxy-3'-Fluorouridine is a modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel antiviral and anticancer agents, leveraging its halogen and fluorine substitutions to modulate biological activity and metabolic stability. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of experimental antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and polymerase function.
• Pro-drug Development: Serves as a core structure for developing pro-drugs with enhanced cellular uptake and targeted delivery.
• Antiviral Agent Synthesis: Building block for creating potential therapeutic agents against DNA viruses.
• Labeled Compound Synthesis: Can be used as a starting material for preparing isotopically labeled compounds for metabolic tracing studies.
• Medicinal Chemistry: A valuable tool for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.

Basic Information

Product Name	5-Bromo-3'-Deoxy-3'-Fluorouridine
CAS No.	439579-22-3
Molecular Formula	C9H10BrFN2O5
Molecular Weight	325.09 g/mol
Synonyms	5-Bromo-3'-deoxy-3'-fluorouridine; 3'-Deoxy-3'-fluoro-5-bromouridine; 5-Br-3'-F-dU; 1-((2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-bromopyrimidine-2,4(1H,3H)-dione; 5-Bromo-1-(4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Bromo-3'-Deoxy-3'-Fluorouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.