Description

R-Afatinib CAS NO 439081-17-1 is a high-purity, small molecule pharmaceutical intermediate and reference standard. This compound is a key chiral building block in the research and development of targeted cancer therapies, specifically tyrosine kinase inhibitors. It is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in the synthesis of novel oncology drugs and analytical method development.

Application

• Pharmaceutical Intermediate: Critical chiral precursor in the synthesis of Afatinib and related kinase inhibitor APIs.
• Reference Standard: Used for analytical method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical manufacturing.
• Research & Development: Serves as a building block in medicinal chemistry for creating new drug candidates targeting EGFR and other kinases.
• Process Chemistry: Employed in scaling up and optimizing synthetic routes for advanced pharmaceutical ingredients.
• Impurity Standard: Utilized to identify, quantify, and control stereoisomeric impurities in final drug substances.
• Academic Research: Used in university and institutional labs for biochemical and pharmacological studies of kinase signaling pathways.

Basic Information

Product Name	R-Afatinib
CAS No.	439081-17-1
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.94 g/mol
Synonyms	(2R)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-oxolan-3-yl]oxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide; (R)-Afatinib; R-Afatinib Dimaleate (salt form); BIBW 2992 (R-enantiomer); Afatinib Impurity; (R)-N-[4-(3-Chloro-4-fluoroanilino)-7-[(S)-(tetrahydrofuran-3-yl)oxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
EINECS	Contact for details

Quality Control

Our R-Afatinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.