Description

Marizomib is a potent, irreversible proteasome inhibitor belonging to the class of β-lactone derivatives. This compound is of significant interest for its unique mechanism of action and its role in advancing research into targeted cancer therapies. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and hematology for the investigation of novel treatment pathways. The global availability of Marizomib CAS NO 437742-34-2 supports critical drug discovery and development programs.

Application

• Oncology Research: A key investigational agent for studying proteasome inhibition in various cancer cell lines and preclinical models.
• Hematological Malignancy Studies: Used in research targeting multiple myeloma, leukemia, and lymphoma due to its distinct activity profile.
• Biochemical Pathway Analysis: Employed as a tool compound to elucidate the role of the proteasome in cellular protein degradation and signaling pathways.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis and development of new therapeutic entities.
• Pharmacological Profiling: Utilized in in vitro and in vivo studies to assess efficacy, pharmacokinetics, and toxicology.

Basic Information

Product Name	Marizomib
CAS No.	437742-34-2
Molecular Formula	C15H25N3O4S
Molecular Weight	343.44 g/mol
Synonyms	NPI-0052; Salinosporamide A; Marizomib (Salinosporamide A); (1R,4R,5S)-4-(2-Chloroethyl)-1-((S)-2-cyclohexyl-2-((S)-2-methyloxirane-2-carboxamido)acetamido)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione; Salinosporamide; LDP-341 analog
EINECS	Contact for details

Quality Control

Our Marizomib is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research purposes. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (IR, MS), and determination of residual solvents. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.