Description

2,2'-Anhydro-L-Thymidine is a high-purity nucleoside analog derivative, a key synthetic intermediate in the production of advanced pharmaceutical compounds. Its value lies in its role as a crucial building block for the synthesis of novel antiviral and anticancer agents, particularly within the field of modified oligonucleotides. This product is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of L-nucleoside analogs, such as Telbivudine and other antiviral drugs.
• Antiviral Drug Research: Serves as a building block for the development of novel therapeutics targeting hepatitis B (HBV) and other viral infections.
• Anticancer Agent Development: Used in the research and production of nucleoside-based chemotherapeutic agents.
• Oligonucleotide Synthesis: An important monomer for creating modified DNA/RNA strands in antisense and siRNA therapeutic platforms.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleoside metabolism pathways.
• Process Development: Used in scaling up and optimizing manufacturing routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2,2'-Anhydro-L-Thymidine
CAS No.	433733-92-7
Molecular Formula	C10H12N2O4
Molecular Weight	224.21 g/mol
Synonyms	L-2,2'-Anhydrothymidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; β-L-2,2'-Anhydrothymidine; L-Thymidine, 2,2'-anhydro-; Anhydro-L-thymidine; L-dT Anhydronucleoside; L-ANA-T
EINECS	Contact for details

Quality Control

Our 2,2'-Anhydro-L-Thymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.