Description

5-Fluoro-2-Methoxybenzyl Alcohol is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the synergistic reactivity of the benzyl alcohol group and the strategic fluorine substitution on the methoxybenzene scaffold, enabling precise molecular modifications. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its influence on molecular polarity and alignment.
• Functional Polymer Modification: Employed to introduce fluorinated aromatic side chains into polymers, altering their thermal, chemical, and surface properties.
• Cross-Coupling Reactions: The benzyl alcohol moiety can be transformed into halides or esters for use in Suzuki, Heck, and other palladium-catalyzed coupling reactions.
• Asymmetric Catalysis Ligand Precursor: Provides a chiral handle for the synthesis of sophisticated ligands used in enantioselective catalysis.

Basic Information

Product Name	5-Fluoro-2-Methoxybenzyl Alcohol
CAS No.	426831-32-5
Molecular Formula	C8H9FO2
Molecular Weight	156.15 g/mol
Synonyms	(5-Fluoro-2-methoxyphenyl)methanol; 2-Methoxy-5-fluorobenzyl Alcohol; 5-Fluoro-o-anisyl Alcohol; 5-Fluoro-2-methoxybenzenemethanol; 1-(5-Fluoro-2-methoxyphenyl)methanol; 5-Fluoro-2-methoxybenzylalcohol; 426831-32-5; 5-Fluoro-2-methoxy benzyl alcohol
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methoxybenzyl Alcohol is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material upon request, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.